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Anti-Golgi antibodies were first described in 1982 in a patient with Sjögren's syndrome (SjS) with a lymphoma.1 They have mainly been reported in patients with SjS and systemic lupus erythematosus (SLE),2 3 but also in patients with other systemic autoimmune diseases such as rheumatoid arthritis4 and non-autoimmune disorders such as idiopathic cerebellar ataxia5 and HIV infection.6 Transient low titres have also been reported in patients with a probable viral infection.7
Anti-Golgi antibodies are rare3 and give a characteristic speckled staining on indirect immunofluorescence composed of irregular granules adjacent to one side of the nucleus. Different autoantigens have been identified including giantin/macrogolgin and different golgins,8 but …
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