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Autoantibodies
Anti-CCP antibodies are a collection of ACPA that are cross-reactive to multiple citrullinated antigens
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  1. A Ioan-Facsinay1,
  2. H el-Bannoudi1,
  3. H U Scherer1,
  4. D van der Woude1,
  5. H A Ménard2,
  6. M Lora2,
  7. L A Trouw1,
  8. T W J Huizinga1,
  9. R E M Toes1
  1. 1Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
  2. 2Division of Rheumatology, McGill University Health Center, Montreal, Quebec, Canada

https://doi.org/10.1136/ard.2010.129577s

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    Objective

    Anti-citrullinated protein/peptide antibodies (ACPA/anti-CCP) are a hallmark of rheumatoid arthritis and are believed to play a role in disease pathogenesis. These antibodies are typically detected in ELISA with citrullinated peptides (eg, CCP2) or -proteins as antigens. The absolute concentration of anti-CCP antibodies in serum is unknown. Although …

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