Peripheral blood CD4 T cell gene expression profiles as predictive biomarkers in early arthritis
- Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, UK
CD4 T cells are thought to play a crucial role in the pathogenesis of rheumatoid arthritis (RA). Diagnosing the condition, particularly among patients who are seronegative for anticyclic citrullinated peptide (ACPA) antibodies, remains challenging in the clinic. The authors have explored the peripheral blood CD4 T cell transcriptome of early arthritis clinic attendees, looking for biomarkers of potential diagnostic utility.
Total RNA from highly purified peripheral blood CD4 T cells of consenting patients with early arthritis naive to …