Article Text
T cells
Single injection of antigen-specific regulatory Tr1 lymphocytes protects mice from severe collagen-induced arthritis
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Introduction
Tr1 cells have been characterised as induced T regulatory lymphocytes (Treg) inhibiting inflammation in various chronic inflammatory models. Based on these data, a clinical trial is ongoing in Crohn's disease. However, the therapeutic potential of these cells has not yet been evaluated in rheumatoid arthritis.
Methods
Collagen type II specific …