Article Text
T cells
MicroRNA-182 promotes clonal expansion of activated T helper cells
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Upon activation by antigen, T lymphocytes switch from a resting state to clonal expansion. This switch requires inactivation of the forkhead transcription factor Foxo1, which suppresses proliferation in resting T helper lymphocytes. In the initial antigen-dependent phase of clonal expansion, Foxo1 is inactivated by antigen receptor-dependent post-translational modifications. …