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Histopathological modifications in haemophilic synovial tissue
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  1. L Ibba-Manneschi,
  2. D Melchiorre,
  3. A F Milia,
  4. M Manetti,
  5. G Benelli,
  6. E Romano,
  7. S Guiducci,
  8. S Linari,
  9. M Morfini,
  10. M Innocenti,
  11. M Matucci-Cerinic
  1. University of Florence, Italy

https://doi.org/10.1136/ard.2010.129650l

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    Background

    Haemophilia is characterised by spontaneous bleeding, mainly in the larger joints. Repeated bleeding episodes lead to synovitis and then to haemophilic arthropathy (HA) with synovial changes, cartilage damage and bone remodelling which result in disability. The pathogenesis of this blood-induced cartilage damage is very little known, but it has been suggested that the recurrent presence of blood induces synoviocyte hypertrophy and hyperplasia with intense neovascularisation and inflammation of the synovial membrane. This results in the production of catabolic enzymes and cytokines by inflammatory cells which induce and exacerbate the pathological process.

    Objectives

    To …

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