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Effects of immunosuppressive treatment on leukotriene pathway in polymyositis and dermatomyositis
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  1. I Loell,
  2. L Alemo-Munters,
  3. C Ottosson,
  4. M Korotkova
  1. Karolinska Institutet, Sweden

https://doi.org/10.1136/ard.2010.129650i

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    Background

    Polymyositis (PM) and dermatomyositis (DM) are characterised by infiltration of macrophages and T cells in skeletal muscle tissue. Immunosuppressive treatment has limited effects on the number of T cells in myositis, providing a basis for persistent immune reaction targeting muscle fibres. Leukotriene B4 (LTB4) is a powerful chemoattractant for myeloid leucocytes and activated T cells into inflamed tissue. LTB4 is formed from arachidonic acid by 5-lipoxygenase (5-LO), 5-LO activating protein (FLAP), and leukotriene A4 hydrolase. Enhanced expression of 5-LO …

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