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Adoptive cellular gene therapy of autoimmune arthritis using a combination of lentivirally transduced dendritic cells
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  1. U Purath,
  2. R J Creusot,
  3. C Garrison Fathman,
  4. U Müller-Ladner,
  5. E Neumann,
  6. I H Tarner
  1. Department of Internal Medicine and Rheumatology, Justus-Liebig-University Giessen, Division of Rheumatology and Clinical Immunology, Kerckhoff-Klinik, Bad Nauheim, Germany

https://doi.org/10.1136/ard.2010.129650a

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    Purpose

    In order to minimise systemic side effects of immune-modulating therapy in rheumatoid arthritis (RA), local delivery of anti-inflammatory molecules to the inflamed joints would be desirable. Immune cells are promising vehicle cells for site-specific gene transfer because of their ability to migrate into inflamed tissues such as arthritic joints. In previous studies we have shown that gene transfer of single anti-inflammatory molecules by genetically modified lymphocytes prevents the onset of arthritis in collagen-induced arthritis (CIA) but does not ameliorate established disease …

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