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  • Nuclear factor-κB (NF-κB) inducing kinase is preferentially expressed in rheumatoid arthritis synovial tissue containing ectopic lymphoid neogenesis

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Nuclear factor-κB (NF-κB) inducing kinase is preferentially expressed in rheumatoid arthritis synovial tissue containing ectopic lymphoid neogenesis
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  1. A-R Noort,
  2. K P M van Zoest,
  3. M Modesti,
  4. S W Tas,
  5. P P Tak
  1. Academic Medical Center/University of Amsterdam, The Netherlands

https://doi.org/10.1136/ard.2010.129643z

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    Background and Objectives

    In approximately 30% of patients with rheumatoid arthritis (RA), synovial inflammation is characterised by ectopic lymphoid neogenesis (ELN) resulting in ‘germinal centre-like' structures that contain dendritic cells (DC) and aggregates of B and T cells. This process does not define a specific disease subset and also occurs in other types of chronic inflammation. Nuclear factor-κB (NF-κB) transcription factors are essential for the expression of proinflammatory cytokines and they induce regulatory circuits. These regulatory properties are thought …

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