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Interleukin-6 is not a crucial regulator in tumour necrosis factor-mediated bilateral sacroiliitis
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  1. S Hayer,
  2. B Niederreiter,
  3. I Nagelreiter,
  4. J Smolen,
  5. K Redlich
  1. Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria

https://doi.org/10.1136/ard.2010.129643c

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    Objective

    To investigate the role of interleukin 6 (IL6) in the pathogenesis of bilateral erosive sacroiliitis in hTNFtg mice, an animal model of ankylosing spondylitis (AS).

    Methods

    We crossed IL6−/− mice with hTNFtg animals to generate IL6−/−hTNFtg mice. Histopathological sections of bilateral sacroiliac joints were …

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