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Novel therapeutic targets
Alarmins S100A8 AND S100A9 skew chondrocytes towards a cartilage breakdown phenotype
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  1. R F P Schelbergen,
  2. P L E M van Lent,
  3. A B Blom,
  4. A Sloetjes,
  5. T Vogl,
  6. J Roth,
  7. W B van den Berg
  1. Department of Rheumatology, Radboud University Medical Centre, Nijmegen, The Netherlands

https://doi.org/10.1136/ard.2010.129635c

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    Background and Objective

    Alarmins S100A8 and S100A9 are members of the S100 family of Ca2+-binding proteins that are involved in the pathology of rheumatoid arthritis (RA). These molecules are released in large amounts by activated macrophages or monocytes either as monomers or as a heterodimeric complex. From arthritis studies in S100A9 knockout mice,1 it appears that S100A8 and S100A9 play an essential role in cartilage degradation. We …

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