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Innate immunity
Regulation of interleukin-1ββ dihydroxyvitamin D3 in human macrophages
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  1. J D Ji1,
  2. Y Kim2,
  3. B Lee3,
  4. T-H Kim3,
  5. J-B Jun3,
  6. D-H Yoo3,
  7. J H Woo1,
  8. S J Choi1,
  9. Y H Lee1,
  10. J Sohn2,
  11. G G Song1
  1. 1Department of Rheumatology, College of Medicine, Korea University, Seoul, Korea
  2. 2Department of Biochemistry, College of Medicine, Korea University, Seoul, Korea
  3. 3The Hospital for Rheumatic Diseases, Hanyang University, Seoul, Korea

https://doi.org/10.1136/ard.2010.129627u

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    1,25-dihydroxyvitamin D3 (1,25(OH)2D3) is a key molecule for maintaining calcium homeostasis and bone metabolism. In addition to these classic actions, 1,25(OH)2D3 has important functions in the immune system. It inhibits proinflammatory T cells such as Th1 and Th17 cells, directly inhibits interferon γ and interleukin 2 (IL2) …

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