JKTBP (hnRNPDL) is a novel toll7/9 dependent target in humans and animal models of inflammatory rheumatic diseases
- B Marklein1,
- Z Konthur2,
- A Cope3,
- M Shlomchik4,
- G Burmester1,
- K Skriner1
- 1Department of Rheumatology and Clinical Immunology, Humboldt University and Free University, Germany
- 2Department of Vertebrate Genomics, Max-Planck Institute for Molecular Genetics, Berlin, Germany
- 3Department of Rheumatology, King's College School of Medicine, London, UK
- 4Yale School of Medicine, New Haven, Connecticut, USA
Objective
Autoimmune diseases are characterised and regularly diagnosed by the presence of autoantibodies to heterogeneous nuclear RNP (hnRNP) autoantigens. These proteins represent a group of autoantigens which are targeted by autoantibodies from patients with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and mixed connective tissue disease. The authors investigated a new member of the hnRNP family targeted by autoantibodies and tested a combination of hnRNPs in humans and …
