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Macrophage stimulation by angiopoietins-1 and -2 promotes recruitment and retention of white blood cells at sites of inflammation
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  1. S Krausz,
  2. M E Sanders,
  3. P P Tak,
  4. K A Reedquist
  1. Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, The Netherlands

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Background

The authors have previously found that macrophages are predominant targets of the angiogenic factors angiopoietin (Ang)-1 and -2 in synovial tissue of patients with rheumatoid arthritis (RA). How macrophage Tie2 ligation by Ang might contribute to disease in RA is currently …

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