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Bone/cartilage biology
Bone cell activity influences bone fragility and fracture risk
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  1. J Caetano-Lopes1,
  2. I Aleixo1,
  3. A Rodrigues1,2,
  4. I P Perpétuo1,
  5. D Fernandes1,
  6. A Lopes1,
  7. A Pena1,
  8. A Faustino1,
  9. M Vale1,3,
  10. P M Amaral4,
  11. J Monteiro3,
  12. M F Vaz4,
  13. H Canhão1,2,
  14. J E Fonseca1,2
  1. 1Rheumatology Research Unit, Instituto de Medicina Molecular da Faculdade de Medicina de Lisboa, Lisbon, Portugal
  2. 2Rheumatology and Bone Metabolic Disorders Department, Hospital de Santa Maria, Tavira, Portugal
  3. 3Ortopaedics Department, Hospital de Santa Maria, Tavira, Portugal
  4. 4Departamento de Engenharia de Materiais, Instituto Superior Técnico, Lisbon, Portugal

https://doi.org/10.1136/ard.2010.129593m

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    Background

    Osteoporosis is a systemic skeletal disease characterised by low bone mass, deterioration in microarchitecture, increased bone fragility and susceptibility to fracture. Besides structural properties, biological phenomena driven by differential gene expression could also contribute to the individual diversity of the structural and mechanical properties of bone that ultimately are reflected in different risks of fracture. The fracture risk assessment tool (FRAX) is an algorithm that takes into account clinical risk factors for fracture and dual energy x-ray absorptiometry results. It has been found …

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