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Autoantibodies
Anti-ATP synthase autoantibodies alter endothelial cell (EC) survival by disrupting pH regulation in vasculit
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  1. C Jamin,
  2. J-E Alard,
  3. J-O Pers,
  4. P Youinou
  1. EA 2216 ‘Immunologie et Pathologie’ and IFR 148 ScInBioS, Université de Brest, and Université Européenne de Bretagne, Brest, France

https://doi.org/10.1136/ard.2010.129577y

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    Background

    B-cell clusters represent genuine germinal centres (GCs) in the SGs of SS patients, but their majority display transitional and marginal zone (MZ)-like B cell characteristics. We thus asked the question as to whether TLR9 stimulation that occurs during inflammatory reaction could influence such an aberrant B-cell differentiation. …

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