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Ann Rheum Dis 69:i67-i71 doi:10.1136/ard.2009.119388
  • Papers
  • Supplement

XBP1: the last two decades

  1. L H Glimcher1,2
  1. 1
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
  2. 2
    Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
  1. Correspondence to Dr L H Glimcher, Department of Immunology and Infectious Diseases, Harvard School of Public Health, 651 Huntington Avenue, FXB 205, Boston, MA 02115, USA; lglimche{at}hsph.harvard.edu
  • Accepted 22 July 2009

Abstract

The transcription factor X box-binding protein 1 (XBP1) was isolated two decades ago in a search for regulators of major histocompatibility complex (MHC) class II gene expression. Many years of research finally revealed a protein with many functions, none of them related to the MHC. This paper provided an overview of what this multifunctional transcription factor actually does.

Footnotes

  • Competing interests None.

  • Provenance and Peer review Not commissioned; externally peer reviewed.