XBP1: the last two decades
- 1Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA
- 2Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
- Correspondence to Dr L H Glimcher, Department of Immunology and Infectious Diseases, Harvard School of Public Health, 651 Huntington Avenue, FXB 205, Boston, MA 02115, USA;
- Accepted 22 July 2009
The transcription factor X box-binding protein 1 (XBP1) was isolated two decades ago in a search for regulators of major histocompatibility complex (MHC) class II gene expression. Many years of research finally revealed a protein with many functions, none of them related to the MHC. This paper provided an overview of what this multifunctional transcription factor actually does.
Competing interests None.
Provenance and Peer review Not commissioned; externally peer reviewed.