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Ann Rheum Dis 69:i65-i66 doi:10.1136/ard.2009.117135
  • Papers
  • Supplement

Treg and lupus

  1. M Bonelli,
  2. J S Smolen,
  3. C Scheinecker
  1. Division of Rheumatology, Department of Medicine III, Medical University of Vienna, Vienna, Austria
  1. Correspondence to Dr C Scheinecker, University of Vienna, Waehringer Guertel 18-20 Vienna A-1090, Austria; clemens.scheinecker{at}meduniwien.ac.at
  • Accepted 23 June 2009

Abstract

Autoimmune diseases such as systemic lupus erythemathodes (SLE) display quantitative and/or qualitative deficiencies of CD4+CD25+ regulatory T cells (Treg). This might contribute to the immune dysregulation and break-down of peripheral tolerance mechanisms. In addition novel subsets of Treg might arise under specific autoimmune conditions as an effort to counteract autoimmunity. Advances in our understanding of how to characterise and manipulate Treg in patients with autoimmune diseases are required in order to develop new therapeutic strategies.

Footnotes

  • Competing interests None.

  • Provenance and Peer review Not commissioned; externally peer reviewed.