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Advances in targeted therapies XI
  1. F C Breedveld,
  2. J R Kalden,
  3. J S Smolen
  1. Correspondence to Professor F C Breedveld, LUMC, PO Box Leiden, Leiden 2300 RC, The Netherlands; f.c.breedveld{at}

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The papers brought together in this supplement of the Annals of the Rheumatic Diseases constitute summaries of presentations at the XIth International Symposium on Advances in Targeted Therapies, which was held from 22 to 26 April 2009. These presentations represent the state of the art on the biology of mechanisms of action and pathophysiology of tumour necrosis factor (TNF) as well as other important mediators of inflammation. Current knowledge on the means and consequences of blocking TNF or other molecules or cellular mechanisms is also presented.

We are grateful to Drs Crofford, Feldmann, Furst, Klareskog, Lipsky, …

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