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The SLC22A12 gene is associated with gout in Han Chinese and Solomon Islanders
  1. Hung-Pin Tu1,2,
  2. Chung-Jen Chen3,
  3. Chien-Hung Lee4,
  4. Silent Tovosia5,
  5. Albert Min-Shan Ko6,
  6. Shu-Jung Wang6,
  7. Tsan-Teng Ou7,
  8. Gau-Tyan Lin8,
  9. Shang-Lun Chiang6,
  10. Hung-Che Chiang9,
  11. Ping-Ho Chen9,
  12. Shun-Jen Chang2,
  13. Han-Ming Lai3,
  14. Ying-Chin Ko2,6,9
  1. 1Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
  2. 2Department of Public Health and Environmental Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
  3. 3Division of Rheumatology, Allergy and Immunology, Department of Internal Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
  4. 4Department of Public Health, Kaohsiung Medical University, Kaohsiung, Taiwan
  5. 5National Referral Hospital, Ministry of Health and Medical Services, Honiara, Solomon Islands
  6. 6Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
  7. 7Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
  8. 8Department of Orthopaedic Surgery, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
  9. 9Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Taipei, Taiwan
  1. Correspondence to Ying-Chin Ko, Department of Public Health and Environmental Medicine, College of Medicine, Kaohsiung Medical University, 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan; ycko{at}kmu.edu.tw

https://doi.org/10.1136/ard.2009.114504

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    Gout is characterised by monosodium urate crystals in hyperuricaemic individuals.1 2 Impaired excretion of urate exacerbates this condition.1 Urate transporter 1 (encoded by SLC22A12) is an urate–anion exchanger in the kidneys mediating urate transportation across the apical membrane of the proximal tubules.3 4 SLC22A12 has been reported to influence urate homeostasis in Caucasian and Japanese populations5,–,8 but single nucleotide polymorphism (SNP) genotype effects on gout are unclear. We studied four SLC22A12 SNP associations with gout and urate levels in male Han Chinese from Taiwan and Solomon Islanders.

    Clinical rheumatologists confirmed gout/tophi cases using American College of Rheumatology (ACR) criteria.9 Our controls had no diagnosis of gout and were not medicated with hypouricaemic agents during outpatient visits. We enrolled 115 …

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    Footnotes

    • Funding This study was supported by grants from the National Health Research Institutes (NHRI-98A1-PDCO-0307101), Center of Excellence for Environmental Medicine, Kaohsiung Medical University, (KMU-EM-98-1-1) and the National Science Council (NSC97–2314-B-037-007 and NSC97–3112-B-400-001).

    • Competing interests None.

    • Patient consent Obtained.

    • Ethics approval This study was conducted with the approval of the Institutional Review Boards of Kaohsiung Medical University, Kaohsiung Chang-Gung Memorial Hospital, the National Health Research Institutes (KMU-IRB:93-063 and NHRI-EC:0940102) and Ethics and Research Committee of the Ministry of Health and Medical Services in the Solomon Islands in September 2006.

    • Provenance and peer review Not commissioned; externally peer reviewed.