Replication of association between FAM167A(C8orf13)-BLK region and rheumatoid arthritis in a Japanese population
- Ikue Ito1,
- Aya Kawasaki1,
- Satoshi Ito2,
- Yuya Kondo2,
- Makoto Sugihara2,
- Masanobu Horikoshi2,
- Taichi Hayashi2,
- Daisuke Goto2,
- Isao Matsumoto2,
- Akito Tsutsumi3,
- Yoshinari Takasaki4,
- Hiroshi Hashimoto5,
- Kunio Matsuta6,
- Takayuki Sumida2,
- Naoyuki Tsuchiya1
- 1Molecular and Genetic Epidemiology Laboratory, Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
- 2Division of Clinical Immunology, Doctoral Program in Clinical Sciences, Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Japan
- 3Takikawa Municipal Hospital, Takikawa, Japan
- 4Division of Rheumatology, Department of Medicine, Juntendo University, Tokyo, Japan
- 5Juntendo University School of Medicine, Tokyo, Japan
- 6Matsuta Clinic, Tokyo, Japan
- Correspondence to Dr Naoyuki Tsuchiya, Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan; tsuchiya-tky{at}umin.net
- Accepted 29 August 2009
- Published Online First 9 September 2009
Polymorphisms in the genomic region encoding B lymphoid tyrosine kinase (BLK) and family with sequence similarity 167, member A (FAM167A, also referred to as C8orf13) at 8p23.1 have been associated with systemic lupus erythematosus (SLE) in Caucasian1 2 and Asian3 4 populations. A recent genome-wide study in a north American population showed new associations with rheumatoid arthritis (RA), among which was a single nucleotide polymorphism (SNP) rs2736340 in the intergenic region of BLK and FAM167A.5 In the HapMap Japanese samples (http://www.hapmap.org/index.html.ja), this SNP is in absolute linkage disequilibrium (r2=1) with rs13277113, previously associated with SLE.1,–,4 We have shown that the population frequency of the risk genotype rs13277113A/A and the OR for SLE …
