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Methotrexate (MTX) is a disease-modifying antirheumatic drug (DMARD) used for the treatment of rheumatoid arthritis (RA). Genetic polymorphisms in AMP deaminase (AMPD1), 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase (ATIC), inosine triphosphate pyrophosphorylase (ITPA) and methylenetetrahydrofolate dehydrogenase (MTHFD1) were shown to be associated with disease activity, MTX treatment response and MTX-induced toxicity in patients with RA.1,–,6 The aim of our study was to test these associations in Slovenian patients with RA treated with MTX.
Our study included 211 patients with RA who were previously characterised.7 Among them, 98 patients were receiving MTX monotherapy, 57 co-treated with one or more DMARD and 56 discontinued MTX before enrolment owing to MTX inefficacy and/or toxicity. The 28-joint count Disease Activity Score (DAS28) …
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