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Leptin is an adipocyte-derived hormone that may regulate the immune response.1 Its reduction is associated with increased susceptibility to infection, whereas the opposite is associated with proinflammatory cytokine production in rheumatoid arthritis (RA) and other autoimmune disorders.2 Leptin could represent a link between the immune response, metabolic functions and nutritional status.3
While the concentration of leptin may be increased in the plasma of patients with RA, in the synovial fluid it seems to be decreased.2 3 Although some reports found no difference between leptin plasma concentrations in patients with RA and healthy controls,4 we found it increased in RA, particularly in those patients with longer disease duration.5 Leptin concentration also correlated with disease …
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