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Occupational risk factors for Wegener's granulomatosis: a case–control study
  1. Ann Knight1,
  2. Sven Sandin2,
  3. Johan Askling3,4
  1. 1Department of Rheumatology, Uppsala University Hospital, Uppsala, Sweden
  2. 2Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
  3. 3Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska University Hospital and Institute, Stockholm, Sweden
  4. 4Rheumatology Unit, Department of Medicine Solna, Karolinska University Hospital and Institute, Stockholm, Sweden
  1. Correspondence to Dr Ann Knight, Department of Rheumatology, Uppsala University Hospital, S-751 85 Uppsala, Sweden; ann.kataja.knight{at}akademiska.se

Abstract

Background Wegener's granulomatosis is a systemic vasculitis of unknown aetiology. Previous studies have presented environmental exposures such as silica and farming as potential risk factors.

Objective To investigate the potential risk for Wegener's granulomatosis associated with occupations involving contact with animals and various airway exposures, using a population-based approach.

Methods In the Swedish Register of inpatient care 2288 cases with Wegener's granulomatosis were identified. Ten matched controls for every case were selected from the Swedish Population Register. By linking the cases and controls to the Swedish population censuses, information on employments before the diagnosis of Wegener's granulomatosis was collected. Relative risks were assessed as odds ratios using conditional logistic regression.

Results Odds ratios for specific occupations ranged from 0.6 to 1.9, and centred symmetrically around 1. No statistically significant increased risk was noted for the investigated occupations.

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Footnotes

  • Ethics approval This study was conducted with the approval of the regional ethics committee in Stockholm, Sweden.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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