Ann Rheum Dis 69:337-344 doi:10.1136/ard.2008.103283
  • Clinical and epidemiological research
  • Extended report

Does anti-mutated citrullinated vimentin have additional value as a serological marker in the diagnostic and prognostic investigation of patients with rheumatoid arthritis? A systematic review

  1. J J Luime,
  2. E M Colin,
  3. J M W Hazes,
  4. E Lubberts
  1. Department of Rheumatology, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, The Netherlands
  1. Correspondence to J J Luime, Erasmus Medical Center, Department of Rheumatology, PO Box 2040, 3000 CA, Rotterdam, The Netherlands; j.luime{at}
  • Accepted 3 March 2009
  • Published Online First 15 March 2009


Objective: To review the diagnostic and prognostic value of anti-mutated citrullinated vimentin (MCV) in rheumatoid arthritis, taking into account the already available serology.

Methods: Medline was searched via PubMed (1966 to May 2008) for anti-MCV and related terms, arthritis and arthropathies. Studies with anti-MCV, arthritis/arthropathy, and primary data on diagnosis and/or prognosis were included. Their methodological quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies (QUADAS) instrument for diagnostic studies and the modified Hayden list for prognostic studies.

Results: Of 14 eligible studies, 11 included diagnostic data and 3 included prognostic data. No study evaluated anti-MCV as an added diagnostic test to the already available anti-cyclic citrullinated peptide (CCP) and rheumatoid factor serology. One study included the optimal patient spectrum resulting in a sensitivity of 0.59 and specificity of 0.98. A total of 10 diagnostic case-control studies using the same anti-MCV kit showed a sensitivity of 0.64–0.84 and a specificity of 0.79–0.96. This almost equalled the performance of anti-CCP in the same studies. The prognostic evaluation of anti-MCV was limited by differences in study methodology, outcome and statistical modelling. Individual studies showed moderate associations for anti-MCV and radiological progression with the strength of the association comparable to that of anti-CCP.

Conclusions: Study heterogeneity, choice of study population and methodological limitations limited overall conclusions about the true diagnostic and prognostic test performance of anti-MCV. Evidence from the diagnostic case-control studies suggests that anti-MCV may be used as an alternative for anti-CCP.


  • ▸ Additional data (supplementary tables 1 and 2 and supplementary appendix) are published online only at

  • Competing interests None declared.

  • Provenance and Peer review Not commissioned; externally peer reviewed.