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Nedd5, a novel autoantigen in systemic sclerosis: is it a marker of more severe disease?
  1. V Riccieri1,
  2. C Alessandri1,
  3. V Germano1,
  4. S Guiducci2,
  5. V Rogai2,
  6. T Colasanti1,
  7. F Delunardo3,
  8. P Margutti3,
  9. E Ortona3,
  10. M Matucci Cerinic2,
  11. G Valesini1
  1. 1
    Department of Clinical Medicine and Therapy, Division of Rheumatology, University Sapienza of Rome, Rome, Italy
  2. 2
    Department of BioMedicine, Division of Rheumatology, AOUC, DENOThe Center, University of Florence, Florence, Italy
  3. 3
    Department of Infective, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy
  1. Correspondence to V Riccieri, Division of Rheumatology, Department of Clinical Medicine and Therapy, University Sapienza of Rome, Viale del Policlinico 155, 00161, Rome, Italy; valeria.riccieri{at}uniroma1.it

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Nedd5 is an intracytoplasmic protein of the septin family, expressed on the endothelial cell surface after apoptotic stimuli, thus behaving as an autoantigen in different autoimmune diseases.1 2 Several cellular signalling pathways, acting either in cell cycle regulation or in apoptosis, may be altered by the upregulation of Nedd5 expression.3 4

Anti-Nedd5 autoantibodies are significantly higher in patients with psychiatric lupus erythematosus and in those affected by systemic sclerosis (SSc).5 Considering that the vascular endothelium has a pivotal position in the pathophysiology of SSc, although the great part of factors provoking the endothelial damage remains unknown,6 the aim of this study was to evaluate anti-Nedd5 serum immunoreactivity responses in patients with SSc and to find out whether it can be associated to the different aspects of this …

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