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Role of European mitochondrial DNA haplogroups in the prevalence of hip osteoarthritis in Galicia, Northern Spain
  1. I Rego1,
  2. M Fernández-Moreno1,
  3. C Fernández-López1,
  4. J J Gómez-Reino2,3,
  5. A González2,
  6. J Arenas4,
  7. F J Blanco1
  1. 1
    Osteoarticular and Aging Research Laboratory, Biomedical Center Research, INIBIC Rheumatology Division, CH Universitario A Coruña, Coruña, Spain
  2. 2
    Laboratorio de Investigacion 10 and Rheumatology Unit, Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain
  3. 3
    Department of Medicine, University of Santiago de Compostela, Spain
  4. 4
    Laboratorio Investigacion Enfermedades Mitocondriales, Hospital 12 de Octubre, Madrid, Spain
  1. Correspondence to Dr F J Blanco, Osteoarticular and Aging Research Laboratory, INIBIC-Hospital Univeristario A Coruña, 15006-A Coruña, Spain; fblagar{at}canalejo.org

Abstract

Objective: To analyse the mitochondrial DNA (mtDNA) haplogroups of patients with hip osteoarthritis (OA) and those of healthy controls in a Spanish population.

Methods: mtDNA haplogroups were assigned to 550 cases of hip OA and 505 clinically asymptomatic controls. Sets of controls with healthy knees and hips (n = 179) and patients with knee and/or hip OA (n = 977) were also analysed in a multivariate analysis after adjusting for sex, age and smoking.

Results: Individuals carrying haplogroup J showed a significantly decreased risk of developing hip OA (OR 0.661; 95% CI 0.440 to 0.993; p = 0.045). In addition to haplogroup J, smoking protected against the development of hip OA (OR 0.543; 95% CI 0.311 to 0.946; p = 0.031). However, no relationship was found between rheumatoid arthritis and mtDNA haplogroups.

Conclusion: The results of this study support the hypothesis that the mtDNA haplogroups have a role in the complex osteoarthritic process.

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Footnotes

  • ▸ Additional data are published online only at http://ard.bmj.com/content/vol69/issue1

  • Funding This study was supported by grants from Fundacion Española de Reumatologia (Proyecto GEN-SER), Instituto de Salud Carlos III (FIS: PI-082028). Secretaría I+D+I Xunta de Galicia (PGIDIT06PXIC916175PN) and from Fondo Investigación Sanitaria (CIBER-BBN CB06/01/0040) Spain, with participation of funds from (FEDER) European Community. IR was supported by Contrato de Apoyo a la Investigación-Fondo Investigación Sanitaria (CA06/01102).

  • Competing interests None.

  • Ethics approval Informed consent was obtained from the patients and the study was approved by the ethical committee of the Galician Health Administration.

  • Provenance and Peer review Not commissioned; externally peer reviewed.

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