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Effects of infliximab therapy on biological markers of synovium activity and cartilage breakdown in patients with rheumatoid arthritis
  1. H Marotte1,
  2. E Gineyts2,
  3. P Miossec1,
  4. P D Delmas2
  1. 1
    Hospices Civils de Lyon-bioMérieux Research Unit on Rheumatoid Arthritis, Hospital Edouard Herriot, Lyon, France
  2. 2
    INSERM Research Unit 831 and University Lyon-1, Lyon, France
  1. Dr H Marotte, Clinical Immunology Unit, Departments of Immunology and Rheumatology and Hospices Civils de Lyon-bioMérieux Research Unit on Rheumatoid Arthritis, Hôpital Edouard Herriot, Pavillon F, 69437 Lyon Cedex 03, France; hubert.marotte{at}laposte.net

Abstract

Background: Defining the remission criteria of rheumatoid arthritis (RA) remains a critical issue. Markers of synovium activity, urinary glucosyl-galactosyl-pyridinoline (Glc-Gal-PYD) and of cartilage destruction, urinary C-terminal crosslinking telopeptide of type II collagen (CTX-II) have been shown to reflect disease activity and joint damage progression in RA.

Methods: The prospective study cohort comprised 66 RA patients treated with infliximab and methotrexate and 76 healthy controls. Measurements of urinary Glc-Gal-PYD and CTX-II were performed at baseline and at 1 year of infliximab therapy.

Results: At baseline, urinary Glc-Gal-PYD and CTX-II levels were increased in patients with RA and correlated with modified Sharp scores and progression of joint damage. Patients with more progressive joint destruction had higher Glc-Gly-PYD and CTX-II baseline levels.

Conclusion: These markers reflected bone erosion evolution and might be useful for treatment monitoring and evaluation of RA. Markers remained high even in clinical responders after infliximab, suggesting persistence of synovitis.

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Footnotes

  • Competing interests: None.

  • Ethics approval: Ethics approval was obtained.

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