Decreased plasma IL22 levels, but not increased IL17 and IL23 levels, correlate with disease activity in patients with systemic lupus erythematosus
- 1Department of Respiratory Medicine, Changhai Hospital, Second Military Medical University, Shanghai, China
- 2Department of Rheumatology and Immunology, Changzheng Hospital, Second Military Medical University, Shanghai, China
- 3Department of Cardiovascular Diseases, Changhai Hospital, Second Military Medical University, Shanghai, China
- Dr Q Li, Department of Respiratory Medicine, Changhai Hospital, 168 Changhai Road, Shanghai 200433, China;
- Accepted 26 July 2008
Interleukin 17 (IL17)-producing T helper (Th17) cells, a new effector T cell subset, appear to play an essential role in autoimmune diseases.1 It has been shown that IL22 is another Th17 cytokine in mice and IL23 is critical for Th17 development.2–5 Increased plasma IL17 levels have been reported in systemic lupus erythematosus (SLE).6 We analysed Th17-related cytokine profiles in the plasma of patients with SLE.
A total of 45 patients with SLE were studied. All patients received glucocorticoids (2.5–50 mg/day). There were 24 patients with active (SLE Disease Activity Index (SLEDAI) score of ⩾6; 22 female; mean (SD) age 37.3 (12.1)) and 21 with inactive …