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Interleukin 17 (IL17)-producing T helper (Th17) cells, a new effector T cell subset, appear to play an essential role in autoimmune diseases.1 It has been shown that IL22 is another Th17 cytokine in mice and IL23 is critical for Th17 development.2–5 Increased plasma IL17 levels have been reported in systemic lupus erythematosus (SLE).6 We analysed Th17-related cytokine profiles in the plasma of patients with SLE.
A total of 45 patients with SLE were studied. All patients received glucocorticoids (2.5–50 mg/day). There were 24 patients with active (SLE Disease Activity Index (SLEDAI) score of ⩾6; 22 female; mean (SD) age 37.3 (12.1)) and 21 with inactive …
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