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Circulating nitrated N-telopeptide of type III collagen (IIINys) as a biochemical marker of oxidative-related synovial tissue metabolism in rheumatoid arthritis
  1. N Charni-Ben Tabassi1,
  2. P Richardot1,
  3. L Toh2,
  4. H Marotte2,
  5. A-C Bay-Jensen3,
  6. P Miossec2,
  7. P Garnero1,4
  1. 1
    Molecular Markers, SYNARC, Lyon, France
  2. 2
    Unité Mixte HCL bioMerieux, E. Herriot Hospital, Lyon, France
  3. 3
    Department of Clinical Cell Biology, IRS/CSFU, University of Southern Denmark, Vejle Hospital, Vejle, Denmark
  4. 4
    INSERM Research Unit 664, Lyon, France
  1. Dr P Garnero, Synarc, 16 rue Montbrillant, 69003 Lyon, France; patrick.garnero{at}synarc.com

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Synovial tissue inflammation plays a major role in mediating joint damage in rheumatoid arthritis (RA).1 An important mediator of inflammation is nitric oxide (NO)2 which is produced by different cells in joint tissues including synoviocytes.3 NO leads to nitration of tyrosine residues producing the post-translational modified nitrotyrosine (Y*).4 Increased immunoreactivity against nitrotyrosine has been shown in synovial tissue from patients with RA although the nature of the proteins and amino acid sequences involved has not been characterised.5 6

We generated a polyclonal antibody directed against the synthetic sequence QY*DSY*DVKSG (IIINys) from the …

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