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Association study of the RANK locus in white European rheumatoid arthritis families
  1. V Hugo Teixeira1,2,
  2. P Dieudé3,
  3. L Michou1,
  4. P Migliorini4,
  5. A Balsa5,
  6. R Westhovens6,
  7. P Barrera7,
  8. H Alves8,
  9. C Vaz8,
  10. M Fernandes8,
  11. D Pascual-Salcedo5,
  12. S Bombardieri4,
  13. J Dequeker6,
  14. T R Radstake7,
  15. P Van Riel7,
  16. L van de Putte7,
  17. A Lopes-Vaz8,
  18. T Bardin9,
  19. F Cornélis1,9,10,11,
  20. for ECRAF,
  21. E Petit-Teixeira1
  1. 1
    GenHotel-EA3886, Evry University, Paris 7 University Medical School, Evry-Genopole, France
  2. 2
    Faculty of Medicine, University of Coimbra, Coimbra, Portugal
  3. 3
    Department of Rheumatology, Medical School, Paris 7 University, Bichat Claude-Bernard Hospital, APHP, Paris, France
  4. 4
    Pisa University, Pisa, Italy
  5. 5
    La Paz Hospital, Madrid, Spain
  6. 6
    KUL Leuven University, Leuven, Belgium
  7. 7
    Nijmegen University, Nijmegen, The Netherlands
  8. 8
    Porto San Joao Hospital, Porto, Portugal
  9. 9
    Rheumatology Federation in Pôle Appareil Locomoteur, Lariboisière Hospital, APHP, Paris, France
  10. 10
    Clinical Genetics Unit in Pôle Laboratoire-Imagerie-Pharmacie Lariboisière Hospital, APHP, Paris, France
  11. 11
    Adult Genetics Unit, Centre Hospitalier Sud Francilien, Corbeil-Essonnes, France
  1. Dr P Dieudé, Department of Rheumatology, Medical School, Bichat Claude-Bernard Hospital, 46 rue Henri Huchard 75877, Paris Cedex 18, France; philippe.dieude{at}

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Rheumatoid arthritis (RA) linkage has been observed on the 18q chromosome in the white population.1 The 18q locus has also shown evidence of linkage with type I insulin-dependent diabetes mellitus, systemic lupus erythematosus and Grave’s disease.2 A candidate gene on chromosome 18q, the TNFRSF11A (RANK) gene, which encodes the receptor activator of nuclear factor kappa B, has been shown to be involved in the osteoclast differentiation playing a pivotal role in bone resorption.3 A single RANK haplotype was reported to be associated with RA in a case–control association study.4 Furthermore, activating mutations in the RANK gene cause bone disorders such as early-onset Paget’s disease,5 expansile skeletal hyperphosphatasia6 and familial expansile osteolysis.7 The aim of this …

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