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Lymph node IL-18 expression in adult-onset Still’s disease
  1. P Conigliaro1,3,
  2. R Priori1,
  3. M Bombardieri2,
  4. C Alessandri1,
  5. F Barone1,2,
  6. C Pitzalis2,
  7. I B McInnes3,
  8. G Valesini1
  1. 1
    Cattedra Di Reumatologia, Dipartimento di Clinica e Terapia Medica, Sapienza Università di Roma, Rome, Italy
  2. 2
    Rheumatology Department, GKT School of Medicine, King’s College, London, UK
  3. 3
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
  1. Professor G Valesini, Dipartimento di Clinica e Terapia Medica, Cattedra di Reumatologia, Sapienza Università di Roma, V le del Policlinico 155, 00161 Roma, Italy; guido.valesini{at}uniroma1.it

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IL-18 is a pleiotropic immunoregulatory cytokine that has been described and implicated in the pathogenesis of a variety of inflammatory diseases.14

Studies in murine models of arthritis and clinical studies suggest that dendritic cells, macrophages and synoviocites within the synovial membrane can produce IL-18.1 57 IL-18 expression has in turn been implicated in the reciprocal regulation of other pro-inflammatory cytokines, such as tumour necrosis factor alpha.8

Recent data clearly demonstrated that IL-18 serum levels were significantly elevated in adult-onset Still’s disease (AOSD) and correlated with disease activity and serum ferritin levels.24 AOSD is characterised by substantial and dysregulated …

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