Juvenile-onset systemic lupus erythematosus: different clinical and serological pattern than adult-onset systemic lupus erythematosus
- I E A Hoffman1,
- B R Lauwerys2,
- F De Keyser3,
- T W J Huizinga4,
- D Isenberg5,
- L Cebecauer6,
- J Dehoorne1,
- R Joos1,
- G Hendrickx7,
- F Houssiau2,
- D Elewaut1
- 1Centre for Paediatric Rheumatology, Ghent University Hospital, Ghent, Belgium
- 2Department of Rheumatology, Université Catholique de Louvain, Louvain, Belgium
- 3Department of Rheumatology, Ghent University Hospital, Ghent, Belgium
- 4Leids Universitair Medisch Centrum, Leiden, Netherlands
- 5University College London, London, UK
- 6Research Institute for Rheumatic Diseases, Piestany, Slovakia
- 7Centre for Paediatric Rheumatology, University of Brussels, Brussels, Belgium
- Dr D Elewaut, Ghent University Hospital, Department of Rheumatology, 185 De Pintelaan, B-9000 Ghent, Belgium;
- Accepted 30 September 2008
- Published Online First 17 October 2008
Objective: To investigate differences in clinical signs and symptoms, and in antinuclear antibodies (ANA), between patients with juvenile-onset and adult-onset systemic lupus erythematosus (SLE).
Methods: Clinical and serological data of 56 patients with juvenile-onset SLE were compared with data of 194 patients with adult-onset SLE. ANA were determined by line immunoassay and by indirect immunofluorescence on Crithidia luciliae.
Results: Renal involvement, encephalopathy and haemolytic anaemia were seen, and anti-dsDNA, anti-ribosomal P and antihistone antibodies found, significantly more often in juvenile-onset SLE. Anti-dsDNA antibodies were directly associated, and anti-ribosomal P antibodies inversely associated, with renal involvement in juvenile-onset SLE. In juvenile patients with SLE and anti-dsDNA and without anti-ribosomal P antibodies the odds ratio for glomerulonephritis was 9.00; no patients with anti-ribosomal P but without anti-dsDNA had renal involvement.
Conclusion: Patients with juvenile-onset SLE more often have renal involvement and encephalopathy than patients with adult-onset SLE. Anti-ribosomal P, anti-dsDNA and antihistone antibodies are more often found in patients with juvenile-onset SLE.
Competing interests: None.
Ethics approval: Approved by the local ethics committees.