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Antinuclear antibodies directed against proliferating cell nuclear antigen are not specifically associated with systemic lupus erythematosus
  1. P Vermeersch1,
  2. K Op De Beeck1,
  3. B R Lauwerys2,
  4. K Van den Bergh1,
  5. M Develter1,
  6. G Mariën1,
  7. F A Houssiau2,
  8. X Bossuyt1
  1. 1
    Department of Laboratory Medicine, Immunology, University Hospitals Leuven, Catholic University of Leuven, Belgium
  2. 2
    Department of Rheumatology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium
  1. Correspondence to Dr X Bossuyt, Laboratory Medicine, Immunology, University Hospitals Leuven, Herestraat 49, B-3000 Leuven, Belgium; Xavier.bossuyt{at}uz.kuleuven.be

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Proliferating cell nuclear antigen (PCNA) is an intranuclear protein that plays a role in DNA repair and replication. Anti-PCNA antibodies are considered a rare but highly specific marker for systemic lupus erythematosus (SLE).1 Anti-PCNA antibodies are reported to occur in approximately 2–6% of patients with SLE.2 3 Given the rare occurrence, however, little is known about the clinical relevance of a positive anti-PCNA test.

To examine whether anti-PCNA antibodies are specifically associated with SLE, we retrospectively identified all patients with anti-PCNA antibodies at the University Hospitals Leuven over a 10-year period (January 1998–December 2007). Patient sera submitted for antinuclear antibody testing were tested by conventional immunofluorescence using Hep2 …

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