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Association of IL2RA and IL2RB with rheumatoid arthritis: a replication study in a Dutch population
  1. F A S Kurreeman1,
  2. N A Daha1,
  3. M Chang2,
  4. J J Catanese2,
  5. A B Begovich2,
  6. T W J Huizinga1,
  7. R E M Toes1
  1. 1
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
  2. 2
    Celera, Alameda, California, USA
  1. Correspondence to Professor R E M Toes, Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands; r.e.m.toes{at}lumc.nl

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Rheumatoid arthritis (RA) is an autoimmune disease with a worldwide prevalence of approximately 1%. The aetiology of RA is largely unknown, but it is thought that both genetic and environmental factors play a role in the pathogenesis of the disease. Genome-wide association studies (GWAS) and candidate gene approaches have led to the association of a number of genetic susceptibility loci.1 2 3 4 5 6 7 The Wellcome Trust case-control consortium (WTCCC), the first GWAS in RA, identified a number of loci reaching genome-wide significance including the HLA region and the PTPN22 gene.5 To identify new genetic risk factors, Thomson et al investigated whether tier 2 single nucleotide polymorphisms (SNPs) (p = 1×10−5−1×10−7) in the WTCCC-GWAS showed an association with RA in an independent validation study …

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