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Erosive progression is minimal, but erosion healing rare, in patients with rheumatoid arthritis treated with adalimumab. A 1 year investigator-initiated follow-up study using high-resolution computed tomography as the primary outcome measure
  1. U Møller Døhn1,
  2. A Boonen2,
  3. M L Hetland1,3,
  4. M S Hansen4,
  5. L S Knudsen4,
  6. A Hansen5,
  7. O R Madsen6,
  8. M Hasselquist7,
  9. J M Møller7,
  10. M Østergaard1,4
  1. 1
    Department of Rheumatology, Copenhagen University Hospital at Hvidovre, Hvidovre, Denmark
  2. 2
    Department of Internal Medicine, Division of Rheumatology, Maastricht University Hospital, Maastricht, The Netherlands
  3. 3
    The DANBIO registry, Copenhagen University Hospital at Hvidovre, Hvidovre, Denmark
  4. 4
    Department of Rheumatology, Copenhagen University Hospital, Herlev, Denmark
  5. 5
    Department of Rheumatology, Copenhagen University Hospital, Rigshospitalet, Denmark
  6. 6
    Department of Rheumatology, Copenhagen University Hospital at Gentofte, Gentofte, Denmark
  7. 7
    Department of Diagnostic Radiology, Copenhagen University Hospital at Herlev, Herlev, Denmark
  1. Correspondence to Dr U Møller Døhn, Department of Rheumatology, Copenhagen University Hospital at Hvidovre, Kettegaard Allé 30, 2650 Hvidovre, Denmark; umd{at}dadlnet.dk

Abstract

Objective: With computed tomography (CT) and radiography, to investigate if repair of bone erosions, defined as regression of erosion scores, occurs during adalimumab treatment of patients with rheumatoid arthritis (RA).

Methods: Fifty-two patients with RA, naïve to biological agents, with at least two low-grade radiographic erosions in the wrist or metacarpophalangeal (MCP) joints in the same (index) hand, initiated adalimumab 40 mg subcutaneously every other week. Thirty-five patients completed the study (median age 61 years (interquartile range 46–68), disease duration 8 years (3–15)). CT of the index wrist and MCP joints 2–5 and radiographs of hands and forefeet were obtained at baseline, 6 and 12 months. Images were evaluated by investigators blinded to chronology and clinical data, and assessed according to Sharp/van der Heijde (radiographs) and OMERACT RA MRI scoring (CT) methods.

Results: Disease activity score, C-reactive protein, tender and swollen joints count and Health Assessment Questionnaire score had all decreased at 6 and 12 months (wilcoxon signed-ranks test p<0.001). No significant change in any imaging parameters of joint destruction was observed at 6 and 12 months. High intrareader agreements were reached (mean intraobserver intraclass coefficients: 0.96 (CT) and 0.97 (radiography)). The number of patients with change scores exceeding the smallest detectable change (SDC) was comparable on CT and radiography, as were the proportions of patients progressing/regressing. Decreased erosion scores at 12 months were registered in 1.6% and 1.8% of sites assessed on CT and radiography, respectively.

Conclusion: Repair of erosions in adalimumab-treated patients with RA is rare, but erosive regression, exceeding the SDC, on CT and radiography occurred. The very limited overall erosive progression supports the view that joint destruction is minimal during adalimumab treatment of patients with RA.

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Footnotes

  • Funding Abbott Denmark and the Danish Rheumatism Association provided financial support for the study.

  • Competing interests MO has received consulting fees, speaking fees and/or research grants from Abbott, Amgen, Bristol-Myers Squibb, Centocor, Genmab, Glaxo-Smith-Kline, Leo Pharma, Novartis, Novo, Pfizer, Roche, Schering-Plough and UCB-Nordic and Wyeth.

  • Ethics approval Approval from the local ethics committee, the Danish Medicines Agency and the Danish Data Protection Agency.

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