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Ann Rheum Dis 2009;68:1528-1534 doi:10.1136/ard.2008.087957
  • Clinical and epidemiological research
  • Extended report

Management of Behçet disease: a systematic literature review for the European League Against Rheumatism evidence-based recommendations for the management of Behçet disease

  1. G Hatemi1,
  2. A Silman2,
  3. D Bang3,
  4. B Bodaghi4,
  5. A M Chamberlain5,
  6. A Gul6,
  7. M H Houman7,
  8. I Kötter8,
  9. I Olivieri9,
  10. C Salvarani10,
  11. P P Sfikakis11,
  12. A Siva12,
  13. M R Stanford13,
  14. N Stübiger14,
  15. S Yurdakul1,
  16. H Yazici1
  1. 1
    Department of Internal Medicine, Division of Rheumatology, Cerrahpasa Medical School, Istanbul University, Istanbul, Turkey
  2. 2
    Epidemiology Unit, Manchester University, Manchester, UK
  3. 3
    Department of Dermatology, Yonsei University, Seoul, South Korea
  4. 4
    Department of Ophthalmology, University of Pierre et Marie Curie, Paris, France
  5. 5
    Rehabilitation Unit, University of Leeds, Leeds, UK
  6. 6
    Department of Internal Medicine, Division of Rheumatology, Istanbul Medical School, Istanbul University, Istanbul, Turkey
  7. 7
    Department of Internal Medicine, University Hospital of la Rabta, Tunis, Tunisia
  8. 8
    Department of Rheumatology, University Hospital, Tübingen, Germany
  9. 9
    Department of Rheumatology, San Carlo Hospital, Potenza, Italy
  10. 10
    Department of Rheumatology, Arcispedale S Maria Nuova, Reggio Emilia, Italy
  11. 11
    Department of Rheumatology, Athens University, Athens, Greece
  12. 12
    Department of Neurology, Istanbul University, Istanbul, Turkey
  13. 13
    Department of Academic Ophthalmology, King’s College London, UK
  14. 14
    Department of Ophthalmology, University Hospital, Tübingen, Germany
  1. Correspondence to H Yazici, Cerrahpasa Tip Fakultesi, Ic Hastaliklari ABD, 34300 Aksaray, Istanbul, Turkey; hyazici{at}attglobal.net
  • Accepted 7 April 2008
  • Published Online First 17 April 2008

Abstract

Objectives: To present and analyse the literature sources regarding the management of Behçet disease (BD) identified during the systematic literature research, which formed the basis for the European League Against Rheumatism (EULAR) evidence-based recommendations for the management of BD.

Methods: Problem areas and related keywords regarding the management of BD were determined by the multidisciplinary expert committee commissioned by EULAR for developing the recommendations. A systematic literature research was performed using MedLine and Cochrane Library resources through to December 2006. Meta-analyses, systematic reviews, randomised controlled trials (RCTs), open studies, observational studies, case control studies and case series’ involving ≥5 patients were included. For each intervention the effect size and number needed to treat were calculated for efficacy. Odds ratios and numbers needed to harm were calculated for safety issues of different treatment modalities where possible.

Results: The literature research yielded 137 articles that met the inclusion criteria; 20 of these were RCTs. There was good evidence supporting the use of azathioprine and ciclosporin A in eye involvement and interferon (IFN)α in mucocutaneous involvement. There were no RCTs with IFNα or tumour necrosis factor (TNF)α antagonists in eye involvement. Similarly controlled data for the management of vascular, gastrointestinal and neurological involvement is lacking.

Conclusion: Properly designed, controlled studies (new and confirmatory) are still needed to guide us in managing BD.

Footnotes

  • Funding This study was supported by the European League Against Rheumatism.

  • Competing interests None declared.

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    1. ard.2008.087957v1
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