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  • Lack of association between HLA-G 14 bp insertion/deletion polymorphism and response to long-term therapy with methotrexate response in rheumatoid arthritis

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Lack of association between HLA-G 14 bp insertion/deletion polymorphism and response to long-term therapy with methotrexate response in rheumatoid arthritis
  1. L K Stamp1,2,
  2. J L O’Donnell1,
  3. P T Chapman1,
  4. M L Barclay3,
  5. M A Kennedy4,
  6. C M A Frampton2,
  7. R L Roberts4
  1. 1
    Department of Rheumatology, Immunology and Allergy, Christchurch Hospital, Christchurch, New Zealand
  2. 2
    Department of Medicine, University of Otago, Christchurch, New Zealand
  3. 3
    Department of Clinical Pharmacology, Christchurch Hospital, Christchurch, New Zealand
  4. 4
    Department of Pathology, University of Otago, Christchurch, New Zealand
  1. L K Stamp, Department of Medicine, University of Otago, Christchurch, P.O. Box 4345, Christchurch 8140, New Zealand; lisa.stamp{at}cdhb.govt.nz

https://doi.org/10.1136/ard.2008.089383

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    Pharmacogenetic studies examining methotrexate (MTX) response/toxicity have focused on enzymes involved in MTX transport and folate metabolism.1 However, recently it has been reported that patients with rheumatoid arthritis (RA) with the HLA-G −/−14 bp genotype are more likely to respond to MTX.2 3 Human leukocyte antigen (HLA)-G molecules are non-classical major histocompatability complex (MHC) class I antigens that play a role in the immune system.4

    We investigated whether an association exists between the HLA-G −/−14 bp polymorphism and response to MTX in a cross-sectional study of patients with RA. Of the 130 patients recruited, 75.4% were female, 81% were rheumatoid factor (RF) positive and 67% …

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    Footnotes

    • Competing interests: None declared.

    • Ethics approval: Ethics approval was obtained.