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Pharmacogenetic studies examining methotrexate (MTX) response/toxicity have focused on enzymes involved in MTX transport and folate metabolism.1 However, recently it has been reported that patients with rheumatoid arthritis (RA) with the HLA-G −/−14 bp genotype are more likely to respond to MTX.2 3 Human leukocyte antigen (HLA)-G molecules are non-classical major histocompatability complex (MHC) class I antigens that play a role in the immune system.4
We investigated whether an association exists between the HLA-G −/−14 bp polymorphism and response to MTX in a cross-sectional study of patients with RA. Of the 130 patients recruited, 75.4% were female, 81% were rheumatoid factor (RF) positive and 67% …
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