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Felson et al make a good case for choosing continuous, rather than dichotomous, variables as the primary outcome measures in randomised controlled trials in rheumatoid arthritis;1 however, outcome measures also need to be meaningful to the clinical community. In TICORA we chose two “co-primary” end-points: first, we employed the mean change in disease activity score (DAS) because this was the most sensitive outcome measure available at the time;2 we also used the achievement of a “good” response according to EULAR criteria because we believed that differences in response rates would be more readily understood. Interestingly, our understanding of the clinical relevance of the outcome measures has been borne out: …
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