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Felty’s syndrome (FS) is associated with rheumatoid arthritis (RA) in conjunction with neutropenia and splenomegaly. The mechanisms underlying neutropenia of FS may involve both cellular and humoral immunity, with a possible role of granulocyte-colony stimulation factor (G-CSF) antibodies.1 Various disease-modifying antirheumatic drugs have been used to treat FS with varying success.2 G-CSF raises neutrophil count and reduces infection in some cases of FS.3 Rituximab, a monoclonal antibody specific for human CD20, which targets B lymphocytes, has been tried in the treatment of FS in the past with mixed results.4 We describe a patient with FS who was treated …
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