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Pharmacogenetic study of 5,10-methylenetetrahydrofolate reductase C677T and thymidylate synthase 3R/2R gene polymorphisms and methotrexate-related toxicity in Chinese Han patients with inflammatory arthritis
  1. Q-Y Zeng,
  2. Y-K Wang,
  3. Z-Y Xiao,
  4. S-B Chen
  1. Department of Rheumatology, The First Affiliated Hospital of Shantou University Medical College, Guangdong, China
  1. Professor Q-Y Zeng, The First Affiliated Hospital of Shantou University Medical College, 57 Chang Ping Road, Shantou, Guangdong 515041, China; qyzeng{at}stu.edu.cn

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Recent studies indicate that polymorphisms C677T in 5,10-methylenetetrahydrofolate reductase (MTHFR) and 5′-untranslated region (UTR) triple or double 28 bp repeat (3R/2R) in thymidylate synthase (TS) are associated with the methotrexate (MTX) toxicity in rheumatoid arthritis (RA), and there are interactions between the two genes.1 We analysed the relationship between these polymorphisms and MTX-related toxicity in 193 Chinese Han consecutive outpatients with inflammatory arthritis who received low-dose MTX treatment (5–15 mg/week, mean (SD) 9.4 (1.9) mg/week). No patients were given folic acid or folinic acid supplements. Table 1 gives the demographic and clinical features of the patients. All subjects were informed and this study was …

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