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Rituximab-related late-onset neutropenia in a patient with severe rheumatoid arthritis
  1. H Marotte1,
  2. G Paintaud2,
  3. H Watier2,
  4. P Miossec1
  1. 1
    Departments of Immunology and Rheumatology, Lyon, France
  2. 2
    François Rabelais University, Tours, France
  1. Professor P Miossec, Clinical Immunology Unit, Departments of Immunology and Rheumatology, Hôpital Edouard Hérriot, 69437 Lyon Cedex 03, France; miossec{at}univ-lyon1.fr

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Rituximab is effective in B-cell lymphomas but also in inflammatory diseases such as rheumatoid arthritis (RA).1 Several cases of late-onset neutropenia (LON) have been described in lymphomas.24 Reversible rituximab-related LON tends to occur 2–6 months after rituximab administration. The post-marketing rate of LON appears very low (<0.02% in a total of 300 000 patients).2 Its mechanism is unknown, although several hypotheses have been suggested.

We report one case of rituximab-related LON for the first time outside the lymphoma field and explore some of the proposed …

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