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Association of the toll-like receptor 4 gene polymorphisms with Behçet’s disease
  1. A Meguro1,
  2. M Ota2,
  3. Y Katsuyama3,
  4. A Oka4,
  5. S Ohno5,
  6. H Inoko4,
  7. N Mizuki1
  1. 1
    Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Kanagawa, Japan
  2. 2
    Department of Legal Medicine, Shinshu University School of Medicine, Nagano, Japan
  3. 3
    Department of Pharmacy, Shinshu University School of Medicine, Nagano, Japan
  4. 4
    Department of Molecular Life Science, Division of Molecular Medical Science and Molecular Medicine, Tokai University School of Medicine, Kanagawa, Japan
  5. 5
    Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Hokkaido, Japan
  1. Nobuhisa Mizuki, Department of Ophthalmology and Visual Science Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan; mizunobu{at}med.yokohama-cu.ac.jp

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Behçet’s disease (BD) is a multisystemic inflammatory disorder characterised by recurrent ocular symptoms, oral and genital ulcers, and skin lesions.1 2 The aetiology of BD remains unclear, but likely both genetic and environmental factors play an important part in BD development.

We performed a whole-genome association analysis of BD using 23 465 microsatellite markers and ultimately found significant association for 147 markers (unpublished data). One of the 147 markers is located within 100 kb from the toll-like receptor (TLR) 4 gene on chromosome 9. Among the TLR family members, TLR4 is the receptor most exhaustively investigated and has been shown to recognise and interact with heat shock protein (HSP) and …

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