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Increased serum levels of soluble triggering receptor expressed on myeloid cells-1 in antineutrophil cytoplasmic antibody-associated vasculitis
  1. T Daikeler1,
  2. S Regenass1,
  3. A Tyndall1,
  4. M M Gencay2,
  5. M Roth2,
  6. M Christ-Crain3,
  7. B Müller3,
  8. C Hess4
  1. 1
    Department of Rheumatology, University Hospital Basel, Switzerland
  2. 2
    Pulmonary Cell Research, Department of Research, University Hospital Basel, Switzerland
  3. 3
    Division of Endocrinology, University Hospital Basel, Switzerland
  4. 4
    Department of Internal Medicine and Immunobiology Laboratory, University Hospital Basel, Switzerland
  1. Thomas Daikeler, Department of Rheumatology, University Hospital Basel Switzerland, Petersgraben 4, CH-4031 Basel Switzerland; tdaikeler{at}uhbs.ch

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Antineutrophil cytoplasmic antibody-associated (ANCA) vasculitis (AAV) is characterised by necrotising inflammation of small vessel walls, largely due to the accumulation and activation of neutrophils. Disease activity can be difficult to assess.1

Triggering receptor expressed on myeloid cells-1 (TREM-1) is an activating receptor expressed on neutrophils and monocytes recruited into sites of bacterial infection.2 3 By contrast, in a number of non-infectious inflammatory diseases (immune complex vasculitis, psoriasis associated arthritis), infiltrating neutrophils were found to lack significant expression of TREM-1.2 A soluble form of TREM-1 (sTREM-1) is shed from the membrane of activated phagocytes, and has been suggested as a …

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