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The prediction of treatment outcome of patients with rheumatoid arthritis (RA) may avoid wasting time and cost of treatment, and allow better targeting of aggressive treatment. Recently, an amino acid-changing polymorphism in the gene encoding the Fcγ IIIA receptor (FcγRIIIA), valine (V)/phenylalanine (F) (rs396991), was found to be associated with increased likelihood of response to tumour necrosis factor (TNF)-α inhibitors in the treatment of RA.1 The aim of the present study was to determine whether this FcγRIIIA V/F polymorphism is associated with treatment outcome of infliximab (the first TNF-α inhibitor approved in Japan) in Japanese patients with RA.
The study was approved by the Tokyo Women’s Medical University Genome Ethics Committee. The …