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Successful treatment with bosentan of non-digital skin ulcers in severe scleroderma
  1. M E G Ferreira,
  2. M A Scheinberg
  1. Hospital Israelita Albert Einstein and Research Institute, São Paulo, Brazil
  1. Professor Morton A Scheinberg, Physician and Research Associate, Hospital Israelita Albert Einstein and Research Institute, Av. Albert Einstein 627, São Paulo, 05651-901, Brazil; morton{at}osite.com.br

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Recurrent digital ulcers are a manifestation of vascular disease in patients with systemic sclerosis leading to severe pain, impaired function and tissue loss. Treatment with the endothelin receptor antagonist, bosentan, has recently been shown to be of benefit in patients with severe Raynaud phenomenon and in the prevention and treatment of digital ulcers in systemic sclerosis.14 To our knowledge, there are no reports in the English literature on the use of bosentan on non-digital …

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