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The B cell in systemic lupus erythaematosus: a rational target for more effective therapy
  1. C B Driver,
  2. M Ishimori,
  3. M H Weisman
  1. Cedars-Sinai Medical Center, Los Angeles, California, USA
  1. Dr M H Weisman, Division of Rheumatology, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, California 90048, USA; weisman{at}cshs.org

Abstract

Current treatment options for systemic lupus erythaematosus (SLE) are diverse and poorly defined, and aggressive therapy can be associated with serious toxicity and tolerability issues. There is, therefore, a need for new and improved treatments to be studied thoroughly in well-designed controlled trials. B Cell dysfunction has emerged as a key pathophysiological component of SLE and is a prime target for the development of new agents for a wide range of lupus severity, including advanced disease. Although many current drugs appear to modify B cell function, the advent of new, targeted therapies offers the hope of improved efficacy and a better long-term tolerability profile.

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Footnotes

  • Funding: Support for the preparation of this manuscript was provided by Genentech, Inc.

  • Competing interests: None declared.

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