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Systemic lupus erythematosus: new molecular targets
  1. José C Crispín,
  2. Vasileios Kyttaris,
  3. Yuang-Taung Juang,
  4. George C Tsokos
  1. Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
  1. George C Tsokos, Beth Israel Deaconess Medical Center, Harvard Medical School, 4 Blackfan Circle, HIM-244, Boston, MA 02115, USA; gtsokos{at}bidmc.harvard.edu

Abstract

T cells from patients with systemic lupus erythematosus exhibit a notable array of defects that probably contribute to the origin and development of the disease. Such abnormalities include an abnormal response to stimulation, aberrant expression of molecules that play key roles in intracellular signalling pathways, altered transcription factor activation and binding, and skewed gene expression. The combination of these alterations leads the cell to the expression of a particular phenotype that intense research has gradually uncovered over the last years. The aim of this article is to review the findings that have allowed us to better understand the behaviour of the lupus T cell and highlight the molecules that represent potential therapeutic targets.

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Footnotes

  • Funding: The work summarised in this article has been supported by DHHS, NIH grants R01AI42269, RO1AI49954 and R01AI068787.

  • Competing interests: None declared.

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