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DNA microarray analysis of labial salivary glands of patients with Sjögren’s syndrome
  1. Ei Wakamatsu,
  2. Yumi Nakamura,
  3. Isao Matsumoto,
  4. Daisuke Goto,
  5. Satoshi Ito,
  6. Akito Tsutsumi,
  7. Takayuki Sumida
  1. Division of Clinical Immunology, Major of Advanced Biochemical Applications, Graduate School Comprehensive Human Science, University of Tsukuba, Ibaraki, Japan
  1. Correspondence to:
    Professor T Sumida
    Division of Clinical Immunology, Major of Advanced Biochemical Applications, Graduate School Comprehensive Human Science, University of Tsukuba, 1-1-1 Tennodai, Tsukuba City, Ibaraki 305-8575, Japan; tsumida{at}md.tsukuba.ac.jp

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Sjögren’s syndrome (SS) is a chronic autoimmune disease characterised by dry eyes, dry mouth and focal lymphocytic infiltration in lacrimal and salivary glands. The infiltrating lymphocytes are mainly CD4 α/β T cells,1 especially T helper 1 (Th1) type T cells, because they produce both interferon (IFN)γ and interleukin 2.2,3 To understand the pathogenesis of SS, several molecules in labial salivary glands (LSGs) have been screened by microarray analysis in human SS. Hjelmervik et al4 and Gottenberg et al5 reported that the upregulated genes in SS salivary glands were IFN-inducible genes, such as IFN-stimulated transcription factor 3, IFN-regulatory factor 1 and B cell-activation factor of the TNF family. …

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