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Imatinib mesylate (Gleevec/Glivec) is a small-molecule inhibitor, which blocks selectively the tyrosine kinase activity of c-abl, bcr-abl, platelet-derived growth factor receptor, c-fms and c-kit.1 It is widely used for the treatment of Philadelphia chromosome-positive leukaemia and gastrointestinal stromal tumours.2,3 Imatinib might also become a novel therapeutic option for pulmonary arterial hypertension.4 Furthermore, imatinib is a potent anti-inflammatory and anti-fibrotic drug, and might be a promising candidate for the treatment of rheumatoid arthritis and systemic sclerosis.5,6
Kerkelä et al7 recently reported on 10 patients who developed congestive heart failure after taking imatinib mesylate. Histological evaluation of cardiac …
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